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Saw Palmetto

Saw palmetto (Serenoa repens) is an herbal DHT inhibitor hair loss remedy tresatment product which is cheaper than most commercial drugs and is claimed to have fewer side effects than finasteride and dutasteride. Unlike other 5-alpha-reductase inhibitors, saw palmetto extract inhibits the conversion of testosterone to DHT without interfering with the cellular capacity to secrete PSA.

Saw palmetto extract has been demonstrated to inhibit both isoforms of alpha-5-reductase unlike finasteride which only inhibits the (predominant) type 2 isoenzyme of alpha-5-reductase.

It must be noted that DHT inhibition in vitro does not necessarily imply inhibition in vivo. A preliminary study of saw palmetto extract for treating hair loss noted improvement in six of ten subjects over a six month period. Dosages were not reported. 

The small size of the study and its relatively short duration limit must be noted.

Regarding Saw Palmetto as a hair loss remedy, there haven't been many studies done showing that Saw Palmetto has any effect on treating hair loss. One study can be found but it was run by the makers of a saw palmetto product, and was publicly labeled as "bunk" on 20/20 in January 2003 on nationwide television because it only included 10 participants and lasted only 6 months.

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